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Un nuevo estudio identifica proteínas reguladas por AMP cíclico en el organismo modelo Dictyostelium discoideum.

A new study identifies proteins regulated by cyclic AMP in the model organism Dictyostelium discoideum.

12/11/19

  • The research carried out by the researchers González and Lacal members of the group at the Center for Cancer Research (CIC-IBMCC) of Bioinformatics and Functional Genomics and the Department of Microbiology and Genetics of the University of Salamanca.

The study, which combines transcriptomic and proteomic data, identifies 110 cyclic AMP (cAMP) novel responsive proteins, an essential compound in the regulation of many biological processes in cells (from bacteria to human cells). In particular, the identified proteins are associated with calcium signaling, adhesion, actin cytoskeleton, protein degradation and metabolism pathways, among other biological processes, that when altered can affect the proper functioning of the cells. These 110 proteins have been identified between two independent studies, one of transcriptomics and one of proteomics, showing a 70% of concordance of the analyzed data.

A wide number of the proteins identified in this study have their equivalent in human cells, while others lack of any characterization and thus have not been previously studied. Some of the proteins identified by the researchers have been previously associated with different human diseases in other studies, and also related to the cAMP role in cells, such as lathosterolosis (a liver disease), neurofibromatosis, Huntington's disease and Alzheimer's disease.

This study, therefore, provides more information on the implications and importance of the cAMP pathway in cell biology. The authors want to highlight the importance of basic research in the generation of knowledge, allowing the creation of potentially new studies in the compression of cell biology, and its possible applications.

 

Paper: https://doi.org/10.3390/cells8101187

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