CD39+ regulatory T cells protect against angiotensin-II-dependent cardiorenal fibrosis AND hypertension
Speaker: Salvatore Fabbiano
Centro de Investigación del Cáncer (CIC-IBMCC), lab 2
Salón de Actos del CIC
Hypertension is the major risk factor for cardiovascular disease. If not controlled, it can lead to cardiorenal dysfunction and failure. In addition, numerous studies in the recent years have addressed the role of the immune response to the generation of proinflammatory and profibrotic programs that sustain cardiorenal diseases and hypertension. However, the cell types involved in these mechanisms are not clear.
Through the analysis of genetically and pharmacologically-induced hypertense mice, we show that the alteration of the normal conventional-regulatory T cell (Tconv-Treg) ratio protects from cardiorenal diseases and leads to milder hypertension. These effects are determined by a Treg subset expressing the ectonucleotidase CD39, which triggers tissue-resident neutrophil apoptosis, inhibiting their proinflammatory and profibrotic activity.