Regulating cell fate decisions through RNA epigenetics
Speaker: Diana Guallar
Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), [Santiago de Compostela- A Coruña]
Host: Alberto Martín Pendás
Salón de Actos del Centro de Investigación del Cáncer
RNA epigenetics, or epitranscriptomics, refers to the post-transcriptional modifications of RNA, and can be found in all kingdoms of life, from archaea to humans. In mammals, more than 40 different chemical modifications have been described (e.g. methylation, pseudouridilation or deamination), and can affect all stages of RNA metabolism, from stability to localization, which play key roles beyond shaping the proteome of the cell. Here, we show that pluripotency acquisition and maintenance themselves are influenced by two RNA modifications: adenosine-to-inosine deamination (A-to-I) and 5-hydroxymethylcytosine (hm5C) modification of RNA, respectively. Moreover, we uncover novel functions of a key leukemia biomarker: the DNA modifying protein TET2, on epitranscriptomics, and shed new light into how RNA modifications can determine cell fate decisions in mammals.