The ins and outs of IL-7R-mediated signaling in leukemia
Speaker: João Barata
Instituto Medicina Molecular [Lisboa, Portugal]
Host: Xosé R. Bustelo
Salón de Actos del Centro de Investigación del Cáncer
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. Combining different in vitro and in vivo models we have been trying to understand how IL-7R-mediated signaling works in leukemic cells (as opposed to normal T cells) and to understand the ways in which deregulated signaling can lead to leukemia development. I will present some of our past work and ongoing work into how IL-7 and IL-7R contribute to leukemogenesis and leukemia expansion.