Host-Microbiota Interactions in Health and Disease
Speaker: Gabriel Núñez
University of Michigan [Michigan, USA]
Host: Pedro A. Lazo-Zbikowski
Salón de actos del Centro de Investigación del Cáncer
The intestinal tract of mammals is colonized by a large number of microorganisms including trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous microorganisms have co-evolved with the host in a symbiotic relationship. In addition to metabolic benefits, symbiotic bacteria provide the host with several functions that promote immune homeostasis and protection against pathogen colonization. Our laboratory is using Citrobacter rodentium, a mouse pathogen that models human infections by enteropathogenic E. coli, to understand the mechanisms by which the microbiota promote clearance of the pathogen in the gut. Bacterial symbionts can also promote disease including inflammatory disorders such as Crohn’s disease in genetically susceptible individuals. We will show new results that demonstrate that particular symbiotic bacteria can accumulate in the intestine and trigger Crohn’s disease-like colitis in mice with mutations relevant to the development of inflammatory bowel disease.