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CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 1

Alberto Fernández Medarde

Role for Ras Guanine Nucleotide Exchange Factors RasGrf1 and RasGrf2 in Central Nervous System


Biography

Role of Ras GEFs RasGrf1 and RasGrf2 in the Central Nervous System. Characterization of the proteins involved in physiological processes regulated by these GEFs: photoreception and memory generation.

Alberto  Fernández Medarde
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research
Projects
  • Fundación Solórzano (2012-2012)

    Papel de los activadores de las oncoproteínas Ras:Sos y RasGrf en procesos fisiolçogicos y su relación con patologías humanas

  • MINISTERIO DE CIENCIA Y TECNOLOGÍA (2003-2005)

    ANALISIS DE LA ESPECIFICIDAD FUNCIONAL DEE LOS INTERCAMBIADORES DE NUCLEOTIDOS DE GUANINA PARA RAS, GRF1 Y GRF2

Publications

(*) Means equal contribution as senior authors.


Patents
Group
  • Dr. Eugenio  Santos Dr. Eugenio Santos

    Dr. Eugenio Santos

    RAS GENE PRODUCTS IN PROLIFERATION AND DIFFERENTIATION SIGNALING PATHWAYS

    Telf.: +34 923 294 801

    Fax:

    Email: esantos@usal.es


    Contact

    Dr. Eugenio Santos de Dios
    Investigador Principal y director del Centro de Investigación del Cáncer
    Laboratorio Nº 1.

    Catedrático, Departamento de Microbiología y Genética de la Universidad de Salamanca.

    923 294 720 (Ext. 4773)
    923 294 743
    cicancer(arroba)usal(.)es

    Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
    Campus Universitario Miguel de Unamuno s/n
    37007 Salamanca
    SPAIN


    Biography

    Dr. Santos received his Ph.D. from the Department of Microbiology, University of Salamanca, in 1978. He carried out postdoctoral training at the Roche Institute of Molecular Biology (Nutley, NJ) (79-81) and the Laboratory of Cellular and Molecular Biology of the National Cancer Institute (NIH, Bethesda, MD) (81-84), where he later remained as a Principal Investigator until 2000, when he rejoined the University of Salamanca as Full Professor of Microbiology and Director of the Cancer Research Institute (USAL-CSIC).

    Dr Santos’s scientific career has evolved closely in step with the field of molecular oncology. As a young postdoc at NCI in the early 1980s he cloned and characterized the first human oncogene (H-ras, from T24 bladder carcinoma cells). Following those seminal contributions that inaugurated the field of human oncogenes, his research has always focused on analysing the structure, function and regulation of the Ras family of genes and proteins. In the 1980s Santos completed the pioneering work of isolating the H-ras oncogene and demonstrating its oncogenic activation by point mutation, by demonstrating, for the first time in humans, the presence of an activated K-ras oncogene in the tumoural tissue – and its absence in the normal tissue – of the same patient. In the 1990s Dr Santos’s laboratory used Ras-dependent proliferation or differentiation models, such as Xenopus oocytes or 3T3L1 pre-adipocytes, to achieve further progress in understanding the structure and function of Ras proteins and their involvement in signal transduction pathways that control cell proliferation and differentiation in eukaryotes. Finally, from 2000 onwards, Santos’s research has demonstrated the functional specificity of the canonical members of the Ras family (H-ras, N-ras and K-ras) and their specific cellular activators (GEF, guanine nucleotide exchange factors) of the GRF and SOS families, using an experimental approach that involves the genomic and proteomic characterization of knockout mouse strains for several Ras and GEF genes.

    Dr Santos is Spain’s national coordinator of the Spanish Cooperative Cancer Research Network (RTICC, sponsored by the Carlos III Health Institute). He sits on several editorial and scientific advisory boards, and has supervised more than fifty postdoctoral and postgraduate researchers throughout his scientific career. Santos is the recipient of several scientific awards, including the Severo Ochoa Award for Biomedical Research (1996) and the Echevarne Oncology Award (2010). He is a member of the Royal Academy of Medicine (RAMSA, Salamanca, Spain, 2003) and of the European Academy of Cancer Sciences (EACS, Brussels, 2011).

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  • Noelia Bautista Estévez Noelia Bautista Estévez

    Noelia Bautista Estévez

    Telf.:

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    Email: n.bautista.estevez@gmail.com


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    Biography
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  • Nuria Calzada Nieto Nuria Calzada Nieto

    Nuria Calzada Nieto

    Telf.:

    Fax:

    Email: nuriacal@usal.es


    Contact

    Biography
    ×
  • María Carranza Jiménez María Carranza Jiménez

    María Carranza Jiménez

    Telf.:

    Fax:

    Email: mcarranza28021996@gmail.com


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    Biography
    ×
  • María Carranza Jiménez María Carranza Jiménez

    María Carranza Jiménez

    Telf.:

    Fax:

    Email: mcarranza28021996@gmail.com


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    Biography
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  • Juan Carlos Fernández Izquierdo Juan Carlos Fernández Izquierdo

    Juan Carlos Fernández Izquierdo

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    Email: juancalamonte@gmail.com


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    Biography
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  • Alberto  Fernández Medarde Alberto Fernández Medarde

    Alberto Fernández Medarde

    Role for Ras Guanine Nucleotide Exchange Factors RasGrf1 and RasGrf2 in Central Nervous System

    Telf.:

    Fax:

    Email: afm@usal.es


    Contact

    Biography

    Role of Ras GEFs RasGrf1 and RasGrf2 in the Central Nervous System. Characterization of the proteins involved in physiological processes regulated by these GEFs: photoreception and memory generation.

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  • Rocío Fuentes Mateos Rocío Fuentes Mateos

    Rocío Fuentes Mateos

    Characterization of the phenotypical alterations in H-Ras & N-Ras double KO mice

    Telf.:

    Fax:

    Email: rocfuemat@gmail.com


    Contact

    Biography
    ×
  • RÓSULA GARCÍA NAVAS RÓSULA GARCÍA NAVAS

    RÓSULA GARCÍA NAVAS

    Telf.:

    Fax:

    Email: ROSULA@USAL.ES


    Contact

    Biography
    ×
  • Carmela Gómez Rodríguez Carmela Gómez Rodríguez

    Carmela Gómez Rodríguez

    Telf.:

    Fax:

    Email: cgomez@usal.es


    Contact

    Biography
    ×
  • David Jimeno García David Jimeno García

    David Jimeno García

    Telf.:

    Fax:

    Email: jimeno@usal.es


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    Biography
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  • Mª Pilar  Liceras Boillos Mª Pilar Liceras Boillos

    Mª Pilar Liceras Boillos

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    Email: pilarliceras@usal.es


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    Biography
    ×
  • Marta López Yus Marta López Yus

    Marta López Yus

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    Email: martalyus@gmail.com


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    Biography
    ×
  • Cynthia Mucientes Valdivieso Cynthia Mucientes Valdivieso

    Cynthia Mucientes Valdivieso

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    Email: idu007744@usal.es


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    Biography
    ×
  • Ophélie Poveda Ophélie Poveda

    Ophélie Poveda

    Telf.:

    Fax:

    Email: poveda.ophelie@gmail.com


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    Biography
    ×

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