• FOLLOW
SPANISH

CENTRO DE INVESTIGACION DEL CANCER

  • Laboratorio 2

Dr. Xosé R. Bustelo

ROLE OF ONCOGENIC MOLECULES AND CYTOSKELETAL REGULATORS IN CANCER AND OTHER HIGH-INCIDENCE DISEASES


Biography

Dr. Bustelo gained his Ph.D at the University of Santiago (Santiago de Compostela, Galicia, Spain) in 1990.


His scientific training outside Spain includes three years (1990-1993) as a postdoctoral fellow at the Bristol Myers Squibb Pharmaceutical Research Institute (Princeton, New Jersey, USA), three years (1993-1996) as a Research Scientist at the same Institution, and four years (1996-1999) as Assistant Professor at the Department of Pathology at the State University of New York (Stony Brook, New York, USA.).


Since his return to Spain (2002), he has been working in the Spanish National Research Council (CSIC) as Tenured Scientist (2000-2004), Staff Scientist (2004-2005), and Full Professor (2005-Present).


His research line focuses on the functional characterization of molecules involved in signal transduction that have oncogenic capacity, with special emphasis on oncoproteins that connect the stimulation of membrane receptors with signalling routes involved in cytoskeletal and mitogenic changes.


His work in this field has been awarded with several national and international scientific awards, including the Catacosinos Young Investigator Award for Cancer Research (1996), the Baldwin Award for Breast Cancer Research (1997), the Sinsheimer Award for Cancer Research (1997) and, more recently, the Echevarne National Oncology Award (2003), the Golden Medal of the Padrón Brotherhood (2006), the Fundación Mutua Madrileña Award (2007), the Pfizer Research Award (2007), and the "Severo Ochoa" Award for Biomedical Research (2007).


His research group has been recognized in 2007 by the Castilla-León Autonomous Government as "Castilla-León Research Group of Excellence".

 

 Dr. Xosé R.  Bustelo
Contact

Centro de Investigación del Cáncer (Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research


Our research is focused on the functional characterization of signal transduction molecules with oncogenic potential and, particularly, on the functional analysis of oncoproteins specialized in connecting the stimulation of membrane receptors with signaling routes that lead to both cytoskeletal change and mitogenic processes. Within this general objetive, the current research of our laboratory is aimed at solving the following biological issues:

(1) Functional characterization of the Vav oncoprotein family, a group of signal transduction molecules that work as phosphorylation-dependent GDP/GTP exchange factors for the GTPases of the Rho/Rac family.

(2) Functional analysis of specific members of Rho/Rac family of GTPases.

(3)Characterization of intracellular positive and negative regulators of Rho/Rac GTPases.

(4) Study of the cross-talk between cytoskeletal routes and other biological processes.

(5) Characterization of the role of these signaling routes in cancer, paying attention to both intrinsic (proliferation, survival, metastasis) and extrinsic (angiogenesis, inflammatory response) pathways that affect the final fitness of tumors in vivo.

(6) Characterization of the role of these signal transduction pathways in other high incidence health problems such as cardiovascular disease and the metabolic syndrome.

(7) Development of new therapeutic avenues to treat those diseases using molecular targets belonging to those signaling routes.

To achieve these aims, our laboratory utilizes a quite diverse collection of experimental tools, including biochemical analysis (i.e., determination of enzyme activities, post-translational modifications, protein-protein interactions), structural biology (i.e., determination of the three-dimensional structure of proteins), cell biology, cell signaling (i.e., characterization of the signaling routes used by the oncoproteins under study) transgenic and knockout mice, genetic models available in invertebrate species (Drosophila, yeast) as well as genomics, proteomics, and cellomics techniques.

To obtain more information on these research objectives, please check the following review articles:

Bustelo, X.R. (2000). Regulatory and signaling properties of the Vav family. Mol. Cell. Biol. 20: 1461-1477.

Bustelo, X.R. (2001). Vav proteins, adaptors and cell signaling. Oncogene 20: 6372-6381.

Bustelo, X.R. (2002). Regulation of Vav proteins by intramolecular events. Frontiers in Bioscience 7: 24-30.

Bustelo, X.R. (2002). Understanding the function of Rho/Rac proteins in T-cells using animal models. Bioessays 24: 602-612.

Bustelo, X.R., Sauzeau, V., and Berenjeno, I.M. (2007). GTP-binding proteins of the Rho/Rac family: regulation, effectors, and functions in vivo. Bioessays 29: 356-370.

Bustelo, X.R. (2008). Vav2. UCSD Nature Molecule Pages (DOI: 10.1038/mp.a002361.01).

Bustelo, X.R. and Couceiro, J.R. (2008). Vav3. UCSD Nature Molecule Pages (DOI: 10.1038/mp.a002362.01).

Bustelo, X.R. (2010). Vav1. UCSD-Nature-Molecule Pages (DOI: 10.1038/mp.a002360.01).

Projects
  • NATIONAL INSTITUTE OF HEALTH (2030-2000)

    Role of VAV family proteins in cell signaling and cáncer

  • Asociación Española Contra el Cáncer (2016-2000)

    Importancia de la GTPasa Oncogénica TC21 en procesos tumorigénicos.

  • MINISTERIO DE CIENCIA Y TECNOLOGIA (2015-2000)

    Regulación y funición de la familia de oncoproteinas VAV

  • Fundación Ramón Areces (2015-2018)

    Ramón Areces Foundation
    Pharmaco-mimetic analysis of the therapeutic role of Vav-dependent metabolic routes in breast cancer.

  • Worldwide Cancer Research (2014-2017)

    Vav proteins: catalytic role in skin tumorigenesis and tumor fate reprogramming (14-1248).

  • Ministerio de Economía y Competitividad (2013-2015)

    Spanish Ministry of Science and Innovation.
    Vav family oncoproteins: new inroads about their regulation, effector routes and potential value as therapeutic targets for high-incidence diseases (SAF2012-31371).

  • Ministerio de Economía y Competitividad/Instituto de Salud Carlos III. (2013-2016)

    Spanish Cancer Cooperative Network / Red Temática de Investigación Cooperativa en Cáncer (RD12/0036/0002)

  • INSTITUTO DE SALUD CARLOS III (2006-2000)

    Papel de laas oncoproeínas VAV en procesos patológicos humanos.

  • Junta de Castilla y León (2003-2000)

    Caracterización del sistema cardiovascular en un modelo animal del síndrome de costello

  • MINISTERIO DE CIENCIA Y TECNOLOGÍA (2001-2000)

    ESPECIFICIDAD FUNCIONAL DE LAS GTPASAS RAS Y RHO/RAC: UNA PERSPECTIVA GENÇOMICA

  • MINISTERIO DE CIENCIA E INNOVACION (2001-2000)

    ONCOPROTEINAS DE LA FAMILIA VAV: REGULACION, SEÑALIZACION Y PARTICIPACION EN PATOLOGIAS HUMANAS

  • JUNTA DE CASTILLA Y LEON (2001-2000)

    Caracterización funcional de una nueva familia de protínas de señalización con potencial oncogénico.

  • FUNDACIÓN RAMÓN ARECES (2001-2000)

    Evolución del transcriptoma durante la oncogénesis y señalización celular promovida por las oncoproteínas.

  • JUNTA DE CASTILLA Y LEÓN (2001-2000)

    Regulación de procesos de señalización celular y oncogénesis por reguladores de GTPASAS RHO/RAC.

  • Junta Castilla y León (2001-2000)

    Unoirtabcua de la GTPASA oncogénica TC21 en cáncer de mama.

  • Junta de Castilla y León (2001-2000)

    Papel de la GTPASA oncogénica TC21 en cáncer de pulmón.

  • Association for International Cancer Research (2001-2000)

    Vav proteins: catalytic role in skin tumorigenesis and tumor fate reprogramming

  • Ministerio de Economía y Competitividad (2001-2000)

    Oncoproteinas de la famila VAV: nuevos avances sobre su regulación, señalización y valor potencial como dianas terapeúticas en enfermedades de alta incidencia

  • Portugal (2001-2000)

    Dotación Becarios Portugal

  • Junta de Castilla y Leon (2001-2000)

    Funciones oncogénicas y fisiológicas de productos de los proto-oncogenes de la familia Vav y Ras

  • Junta de Castilla y Leon (2001-2000)

    Funciones oncogénicas y fisiológicas de productos de los proto-oncogenes de la familia Vav y Ras

  • Consejo Superior de Investigaciones Científicas (2001-2000)

    ONCOPROTEÍNAS DE LA FAMILIA VAV: REGULACIÓN, SEÑALIZACIÓN Y PARTICIPACIÓN EN PATOLOGÍAS HUMANAS

  • Unión Europea (2001-2000)

    Understanding and fighting metastasis via dissection of the core invasive machinery

Junta de Castilla y León Ministerio de economía y competitividad Fondo europeo de desarrollo regional Association for international cancer research Asociación española contra el Cáncer Ministerio de sanidad, servicios sociales e igualdad Red Temática de Investigación Cooperativa en Cáncer
Publications

(*) Means equal contribution as senior authors.



2020
2018
2017
2015
2014

K-RasV14I recapitulates Noonan syndrome in mice.

Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M, 
Proc. Natl. Acad. Sci. U.; 2014-Nov; 111(46); 16395-40; 25359213

VAV3 mediates resistance to breast cancer endocrine therapy.

Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Sacristán M, Bostner J, Karlsson E, Pérez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M, Brunet J, Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M, Villanueva A, Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MA, 
Breast Cancer Res.; 2014-; 16(3); R53; 24886537


2013
2012
2011
2010
2009
2008

Human Proteinpedia enables sharing of human protein data.

Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A, 
Nat. Biotechnol.; 2008-02; 26(2); 164-7; 18259167


2007
2006
2005
2004

Berenjeno IM, Núñez F, Bustelo XR, 
; ; ; ; 17213802

Patents
  • Gene signature for cancer prognosis / Firma genética para el pronóstico del cancer
    Bustelo, X.R., Citterio, C., Menacho-Márquez, M., García-Escudero, R., Paramio, J.M., CIEMAT, CSIC and University of Salamanca
    P201231170; 2012-01-01

  • Animal models and cells derived from them as experimental tools to characterize compounds to treat T cell lymphomas
    Bustelo, X.R., Ruiz, S., Santos, E., University of Salamanca and CSIC
    ES 2 341 213; 2011-01-01

  • Genetically modified non-human mammal, cells and methods for producing same
    Delgado Canaveras Pilar / García Bustelo Xosé Ramón / Martínez Martín Nuria / Calleja Sierra Enrique / Cubelos Álvarez Beatriz / Alarcón Sánchez Balbino José
    ES2351646 (B1); 2009-06-02

  • Animal models and cells derived from them as experimental tools to characterize compounds to treat T cell lymphomas
    Bustelo, X.R., Ruiz, S., Santos, E., University of Salamanca and CSIC
    W0970560ES; 2009-01-01

  • Animal models and derived cells for use thereof in determination of useful compounds in the treatment of T-cell lymphomas
    García Bustelo Xosé Ramón Ruiz Macías Sergio Santos De Dios Eugenio
    ES2341213 (A1) WO2010070170 (A1); 2008-12-15

  • Animal models and derived cells for use thereof in determination of useful compounds in the treatment of T-cell lymphomas
    García Bustelo Xosé Ramón / Ruiz Macías Sergio / Santos De Dios Eugenio
    ES2341213 (A1) WO2010070170 (A1); 2008-12-15

  • Use of non-human mammals lacking expression and/or activity of the Vav2 protein in the cardiovascular, renal and neurological fields
    Bustelo, X.R., Sauzeau, V., University of Salamanca and CSIC
    W07070189ES; 2008-01-01

  • Use of non-human mammals lacking VAV2 protein expression and/or activity in the cardiovascular, kidney and neurological fields
    García Bustelo Xosé Ramón / Sauzeau Vincent
    ES2303454 (A1) WO2008/062091 (A1); 2006-11-21

  • Use of non-human mammals lacking expression and/or activity of the Vav2 protein in the cardiovascular, renal and neurological fields
    Bustelo, X.R., Sauzeau, V., University of Salamanca and CSIC
    P200602969; 2006-01-01

  • Mamífero no humano carente de la expresión del gen VAV3, procedimiento de obtención y sus aplicaciones.
    García Bustelo Xosé R / Sauzeau Vicente
    ES2318921 (B1); 2005-05-18

  • Preparation and use of transgenic mice lacking the expression of the Vav3 proto-oncogene to study models of cardiovascular and nervous disease
    Bustelo, X.R., Sauzeau, V. and CSIC
    ES 2 318 921 B1; 2005-01-01

  • DNA vectors coding for regions of vav1 and vav2 proto-oncogene products (R7209)
    Bustelo, X.R. and The Research Foundation of SUNY at Stony Brook
    R7209; 1997-01-01

Group
  •  Dr. Xosé R.  Bustelo Dr. Xosé R. Bustelo

    Dr. Xosé R. Bustelo

    ROLE OF ONCOGENIC MOLECULES AND CYTOSKELETAL REGULATORS IN CANCER AND OTHER HIGH-INCIDENCE DISEASES

    Telf.:

    Fax:

    Email: xbustelo@usal.es


    Contact

    Dr. Xosé R. Bustelo
    Profesor de Investigación (CSIC)
    Investigador Principal, CIC
    Director, Unidad de Genómica y Proteómica
    Coordinador Nacional, Programa de Genómica, Proteómica y Bioinformática (Red Temática de Investigación Cooperativa en Cáncer)
    Laboratorio 2

    923294802
    923294743
    xbustelo@usal.es

    Centro de Investigación del Cáncer
    Universidad de Salamanca-CSIC
    Campus Unamuno s/n
    E-37007 Salamanca
    España/Spain


    Biography

    Dr. Bustelo gained his Ph.D at the University of Santiago (Santiago de Compostela, Galicia, Spain) in 1990.


    His scientific training outside Spain includes three years (1990-1993) as a postdoctoral fellow at the Bristol Myers Squibb Pharmaceutical Research Institute (Princeton, New Jersey, USA), three years (1993-1996) as a Research Scientist at the same Institution, and four years (1996-1999) as Assistant Professor at the Department of Pathology at the State University of New York (Stony Brook, New York, USA.).


    Since his return to Spain (2002), he has been working in the Spanish National Research Council (CSIC) as Tenured Scientist (2000-2004), Staff Scientist (2004-2005), and Full Professor (2005-Present).


    His research line focuses on the functional characterization of molecules involved in signal transduction that have oncogenic capacity, with special emphasis on oncoproteins that connect the stimulation of membrane receptors with signalling routes involved in cytoskeletal and mitogenic changes.


    His work in this field has been awarded with several national and international scientific awards, including the Catacosinos Young Investigator Award for Cancer Research (1996), the Baldwin Award for Breast Cancer Research (1997), the Sinsheimer Award for Cancer Research (1997) and, more recently, the Echevarne National Oncology Award (2003), the Golden Medal of the Padrón Brotherhood (2006), the Fundación Mutua Madrileña Award (2007), the Pfizer Research Award (2007), and the "Severo Ochoa" Award for Biomedical Research (2007).


    His research group has been recognized in 2007 by the Castilla-León Autonomous Government as "Castilla-León Research Group of Excellence".

     

    ×
  • David Bastante Rodríguez David Bastante Rodríguez

    David Bastante Rodríguez

    Telf.:

    Fax:

    Email: davidbr_10@hotmail.com


    Contact

    Biography
    ×
  • María Teresa Blázquez Ramos María Teresa Blázquez Ramos

    María Teresa Blázquez Ramos

    Telf.:

    Fax:

    Email: mblazquez@usal.es


    Contact

    Biography
    ×
  • Laura  Clavaín Mateo Laura Clavaín Mateo

    Laura Clavaín Mateo

    Telf.:

    Fax:

    Email: lclavain@usal.es


    Contact

    Biography
    ×
  • Javier Conde Aranda Javier Conde Aranda

    Javier Conde Aranda

    Telf.:

    Fax:

    Email: jcondearanda@gmail.com


    Contact

    Biography
    ×
  • Myriam Cuadrado López Myriam Cuadrado López

    Myriam Cuadrado López

    Telf.:

    Fax:

    Email: mcuadrado@usal.es


    Contact

    Biography
    ×
  • Antonio Luis Abad  de Blas Antonio Luis Abad de Blas

    Antonio Luis Abad de Blas

    Telf.:

    Fax:

    Email: aabad@usal.es


    Contact

    Biography
    ×
  • Rubén Fernández Caloto Rubén Fernández Caloto

    Rubén Fernández Caloto

    Telf.:

    Fax:

    Email: ruben.fdez.caloto@gmail.com


    Contact

    Biography
    ×
  • LUCIA  FERNÁNDEZ NEVADO LUCIA FERNÁNDEZ NEVADO

    LUCIA FERNÁNDEZ NEVADO

    Telf.:

    Fax:

    Email: luciaferne@gmail.com


    Contact

    Biography
    ×
  • Natalia Fernández Parejo Natalia Fernández Parejo

    Natalia Fernández Parejo

    Telf.:

    Fax:

    Email: nparejo@usal.es


    Contact

    Biography
    ×
  • Mª Isabel Fernández Pisonero Mª Isabel Fernández Pisonero

    Mª Isabel Fernández Pisonero

    Telf.:

    Fax:

    Email: m_fernandez_pisonero@hotmail.com


    Contact

    Biography
    ×
  • Alba García Liberal Alba García Liberal

    Alba García Liberal

    Telf.:

    Fax:

    Email: alba_liberal@hotmail.com


    Contact

    Biography
    ×
  • Jesús Lacal Romero Jesús Lacal Romero

    Jesús Lacal Romero

    Telf.:

    Fax:

    Email: jlacal@usal.es


    Contact

    Biography
    ×
  • Luis Francisco Lorenzo Martín Luis Francisco Lorenzo Martín

    Luis Francisco Lorenzo Martín

    Telf.:

    Fax:

    Email: Fran_lm@usal.es


    Contact

    Biography
    ×
  • Enrique Madruga Mayordomo Enrique Madruga Mayordomo

    Enrique Madruga Mayordomo

    Telf.:

    Fax:

    Email: enriquemadruga@usal.es


    Contact

    Biography
    ×
  • Sergio Oterino Sogo Sergio Oterino Sogo

    Sergio Oterino Sogo

    Telf.:

    Fax:

    Email: sergiooterino@usal.es


    Contact

    Biography
    ×
  • Javier Robles Valero Javier Robles Valero

    Javier Robles Valero

    Telf.:

    Fax:

    Email: javier.robles.valero@gmail.com


    Contact

    Biography
    ×
  • Sonia Rodríguez Fernández Sonia Rodríguez Fernández

    Sonia Rodríguez Fernández

    Telf.:

    Fax:

    Email: soniarf@usal.es


    Contact

    Biography
    ×

Formers Members

Linkedin Profile