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  • Laboratorio 19

Dr. Javier De Las Rivas

Bioinformatics and Functional Genomics


Biography

MSc in Biology and PhD in Biochemistry and Molecular Biology by the University of the Basque Country (1990). From 1990 to 1993 Post-Doctoral Researcher at the Imperial College of Science, Technology and Medicine (London, UK). From 1993 to 1998 Associate Professor in the Department of Biochemistry and Molecular Biology of the University of the Basque Country at the Faculties of Pharmacy and Science, teaching Biochemistry, Biomolecules and Metabolism Regulation. In 1998 gained a position as "Cientifico Titular" in the CSIC and in 2006 he became "Investigador Cientifico". His research as experimental biochemist focused on biochemical studies on protein structure and function, mainly on redox proteins. Since 1998, he works in the new field of Bioinformatics and Systems Biology, with two stays for specialization in 1998 in the EMBL (Heidelberg, Germany) and in 2000-2001 in the Mount Sinai School of Medicine (New York, USA). Since 2002 he is staff scientist in the CIC (Salamanca, Spain) and leader of a research group in Bioinformatics, Functional Genomics and Systems Biology.

Dr. Javier De Las Rivas
Contact


Dr. Javier De Las Rivas
Grupo de Investigación Bioinformática y Genómica Funcional
Laboratorio 19
WEB PAGE: http://bioinfow.dep.usal.es/

+34 923 294819
+34 923 294743
jrivas(at)usal(.)es

Centro de Investigación del Cáncer (CiC-IBMCC, Universidad de Salamanca-CSIC)
Campus Universitario Miguel de Unamuno s/n
37007 Salamanca
SPAIN

Areas of Research

MSc in Biology and PhD in Biochemistry and Molecular Biology by the University of the Basque Country (1990). From 1990 to 1993 Post-Doctoral Researcher at the Imperial College of Science, Technology and Medicine (London, UK). From 1993 to 1998 Associate Professor in the Department of Biochemistry and Molecular Biology of the University of the Basque Country at the Faculties of Pharmacy and Science, teaching Biochemistry, Biomolecules and Metabolism Regulation. In 1998 gained a position as "Cientifico Titular" in the CSIC and in 2006 he became "Investigador Cientifico". His research as experimental biochemist focused on biochemical studies on protein structure and function, mainly on redox proteins. Since 1998, he works in the new field of Bioinformatics and Systems Biology, with two stays for specialization in 1998 in the EMBL (Heidelberg, Germany) and in 2000-2001 in the Mount Sinai School of Medicine (New York, USA). Since 2002 he is staff scientist in the CIC (Salamanca, Spain) and leader of a research group in Bioinformatics, Functional Genomics and Systems Biology.

Projects
  • JUNTA DE CASTILLA Y LEON (2026-2000)

    Identificación por métodos bioinformáticos de la red de genes que caracterizan un clasificador predictor de hempatías malignas a partir de datos de microarrays de expresión genómica

  • Junta de Castilla y León (2018-2000)

    Transcriptómica y epegenómica de células stem mesenquimales MSC normales y alteradas en hemopatías malignas

  • FUNDACION BBVA (2016-2000)

    Bioinformatics for statistical and functional analisis of geneme-wide expression data from cancer clinical samples

  • JUNTA DE CASTILLA Y LEON (2005-2000)

    Reverse engineering and artificial intelligence applied to genomic data to define gene networks and search for biomarkers in hematological cancer

  • INSTITUTO DE SALUD CARLOS III (2003-2000)

    Análisis estadístico y biológico por métodos bioinformáticas de resultados de chips genómicos de hemopatías malignas.

  • UNIVERSIDAD DE SALAMANCA (2001-2000)

    Modelo tridimensional por métodos computacionales y bioinformáticos de proteinas implicadas en la formación del complejo pre-replicataivo de eucariotas y análisis de estructura y función de sus macro y micro

  • Ministerio de Economía y Competitividad (2001-2000)

    PROTEIN INTERACTOME: Construction a new human protein nteractome Reference Set hsRS-PPl combining proteomic and bioinformatic work; steps to build a more comprehensive human interaction network.

  • Instituto de Salud Carlos III (2001-2000)

    Biología molecular integrativa de hemopatías malignas: análisis bioinformáticas de datos transcriptómicos y proteómicos para identificar genes marcadores, genes causales y redes reguladoras asociadas a subclases patológicas de dos síndromes proliferativos

  • Celgene Research S.L.U. (2001-2000)

    “Sponsored Research Agreement”

  • Instituto de Salud Salud Carlos III (2001-2000)

    ESTUDIO DE REDES FUNCIONALES DE GENES Y PROTEINAS POR METODOS BIOINFORMATICOS A PARTIR DE DATOS GENÓMICOS DE EXPRESIÓN Y DE INTERACCIÓN.

  • Fundación Solorzano (2001-2000)

    Expresión Genómica y cáncer: análisis bioinformática y construcción de un predictor multiclase para leucemias.

  • Instituto de Salud Carlos III (2001-2000)

    Genómica integrativa de leucemias y mieloma: estudio bioinformática de transcriptomas e interactomas a nivel omico para desentrañar los estados patológicos, redes derivadas y nodos críticos de estas enfermedades

Junta de Castilla y León Ministerio de economía y competitividad Fondo europeo de desarrollo regional
Publications

(*) Means equal contribution as senior authors.



2018

Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.

García-Ramírez I, Bhatia S, Rodríguez-Hernández G, González-Herrero I, Walter C, González de Tena-Dávila S, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Domínguez V, Pintado B, Blanco O, Alonso-López D, De Las Rivas J, Martín-Lorenzo A, Jiménez R, García Criado FJ, García Cenador MB, Lossos IS, Vicente-Dueñas C, Borkhardt A, Hauer J, Sánchez-García I, 
EMBO J.; 2018-Jun; 1460-2075; e98783; 29880602


2017

Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases.

Rodríguez-Hernández G, Hauer J, Martín-Lorenzo A, Schafer D, Bartenhagen C, García-Ramírez I, Auer F, González-Herrero I, Ruiz-Roca L, Gombert M, Okpanyi V, Fischer U, Chen C, Dugas M, Bhatia S, Linka RM, Garcia-Suquia M, Rascón-Trincado MV, Garcia-Sanchez A, Blanco O, García-Cenador MB, García-Criado FJ, Cobaleda C, Alonso-López D, De Las Rivas J, Müschen M, Vicente-Dueñas C, Sánchez-García I, Borkhardt A, 
Cancer Res.; 2017-Jun; 1538-7445; canres.0; 28630052

Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice.

García-Ramírez I, Tadros S, González-Herrero I, Martín-Lorenzo A, Rodríguez-Hernández G, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, De Las Rivas J, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, García Criado FJ, García Cenador MB, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR, 
Blood; 2017-Mar; (); ; 28288979


2016
2015

Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach.

Castellanos-Martín A, Castillo-Lluva S, Sáez-Freire Mdel M, Blanco-Gómez A, Hontecillas-Prieto L, Patino-Alonso C, Galindo-Villardón P, Pérez Del Villar L, Martín-Seisdedos C, Isidoro-García M, Abad-Hernández Mdel M, Cruz-Hernandez JJ, Rodríguez-Sánchez CA, González-Sarmiento R, Alonso-López D, De Las Rivas J, García-Cenador B, García-Criado J, Lee do Y, Bowen B, Reindl W, Northen T, Mao JH, Perez-Losada J, 
Genome Biol.; 2015-; 16(); 40; 25853295


2014
2013

Best practices in bioinformatics training for life scientists.

Via A, Blicher T, Bongcam-Rudloff E, Brazas MD, Brooksbank C, Budd A, De Las Rivas J, Dreyer J, Fernandes PL, van Gelder C, Jacob J, Jimenez RC, Loveland J, Moran F, Mulder N, Nyronen T, Rother K, Schneider MV, Attwood TK, 
Brief. Bioinformatics; 2013-09; 14(5); 528-37; 23803301

iAnn: an event sharing platform for the life sciences.

Jimenez RC, Albar JP, Bhak J, Blatter MC, Blicher T, Brazas MD, Brooksbank C, Budd A, De Las Rivas J, Dreyer J, van Driel MA, Dunn MJ, Fernandes PL, van Gelder CW, Hermjakob H, Ioannidis V, Judge DP, Kahlem P, Korpelainen E, Kraus HJ, Loveland J, Mayer C, McDowall J, Moran F, Mulder N, Nyronen T, Rother K, Salazar GA, Schneider R, Via A, Villaveces JM, Yu P, Schneider MV, Attwood TK, Corpas M, 
Bioinformatics; 2013-07; 29(15); 1919-21; 23742982


2012
2013
2012
2011

PSICQUIC and PSISCORE: accessing and scoring molecular interactions.

Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H, 
Nat. Methods; 2011-06; 8(7); 528-9; 21716279


2010
2011
2010
2009
2008
2007

The minimum information required for reporting a molecular interaction experiment (MIMIx).

Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H, 
Nat. Biotechnol.; 2007-08; 25(8); 894-8; 17687370


Gutiérrez NC, Ocio EM, De Las Rivas J, Maiso P, Delgado M, Fermiñán E, Arcos MJ, Sanchez ML, Hernández JM, San Miguel JF, 
; ; ; ; 17252022


2006

[Bone metastases].

Vicent S, Luis-Ravelo D, Antón I, Hernández I, Martínez S, De Las Rivas J, Gúrpide A, Lecanda F, 
An Sist Sanit Navar; 2006-09; 29(2); 177-88; 17001355


2007
2006
2005
Patents
  • Méthode de diagnostic in vitro de patients souffrant d'un lymphome splénique de la zone marginale
    Hernández Rivas Jesús María / García Hernández Juan Luis / Robledo Montero Cristina
    ES2371000 (A1) WO2011154579 (A1); 2010-06-07

  • Uso de sondas para el diagnóstico del linfoma esplenico de la zona marginal
    Hernández Rivas Jesús María / García Hernández Juan Luis
    ES2284408 (A1); 2007-01-30

  • Experimental models for non-microcytic lung cancer metastasis to bone
    Lecanda Cordero Fernando /Vicent Cambra Silvestre / De Las Rivas Sanz Francisco Ja
    WO2008031910 (A2); 2006-09-15

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  • Dr. Javier De Las Rivas Dr. Javier De Las Rivas

    Dr. Javier De Las Rivas

    Bioinformatics and Functional Genomics

    Telf.:

    Fax:

    Email: jrivas@usal.es


    Contact

    Dr. Javier De Las Rivas
    Grupo de Investigación Bioinformática y Genómica Funcional
    Laboratorio 19
    WEB PAGE: http://bioinfow.dep.usal.es/

    +34 923 294819
    +34 923 294743
    jrivas(at)usal(.)es

    Centro de Investigación del Cáncer (CiC-IBMCC, Universidad de Salamanca-CSIC)
    Campus Universitario Miguel de Unamuno s/n
    37007 Salamanca
    SPAIN


    Biography

    MSc in Biology and PhD in Biochemistry and Molecular Biology by the University of the Basque Country (1990). From 1990 to 1993 Post-Doctoral Researcher at the Imperial College of Science, Technology and Medicine (London, UK). From 1993 to 1998 Associate Professor in the Department of Biochemistry and Molecular Biology of the University of the Basque Country at the Faculties of Pharmacy and Science, teaching Biochemistry, Biomolecules and Metabolism Regulation. In 1998 gained a position as "Cientifico Titular" in the CSIC and in 2006 he became "Investigador Cientifico". His research as experimental biochemist focused on biochemical studies on protein structure and function, mainly on redox proteins. Since 1998, he works in the new field of Bioinformatics and Systems Biology, with two stays for specialization in 1998 in the EMBL (Heidelberg, Germany) and in 2000-2001 in the Mount Sinai School of Medicine (New York, USA). Since 2002 he is staff scientist in the CIC (Salamanca, Spain) and leader of a research group in Bioinformatics, Functional Genomics and Systems Biology.

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