Notch and Wnt in normal and leukemic hematopoiesis
Ponente: Anna Bigas
Instituto Hospital del Mar de Investigaciones Médicas (IMIM) [Barcelona, Spain]
Host: Xosé R. Bustelo
Salón de Actos del CIC
The Notch and Wnt pathways are instrumental for the development of most tissues including blood. However, after development, the role in hematopoietic tissue homeostasis becomes less obvious and extremely complex.
My group has studied the function of these signalling pathways and their crosstalk in the hematopoietic system from its origin in the embryo to the aging organism, including their role in leukemic transformation. In this talk, I will cover different mechanistic aspects of Notch and Wnt function that are important in hematopoiesis and leukemia.