Phenotypic Plasticity in Melanoma
Ponente: Berta López Sánchez-Laorden
Instituto de Neurociencias, CSIC-UMH [Alicante, Spain]
Host: Pedro Lazo
Fecha: 23/03/2017 - 23/03/2017
Salón de Actos del Centro de Investigación del Cáncer
Melanoma is the most deadly form of skin cancer. Unfortunately despite the existing public campaigns to prevent melanoma, its incidence continues to increase worldwide. Critically, melanoma heterogeneity, high metastatic ability and resistance to therapies can be attributed to its intrinsic high plasticity. Interestingly, EMT-TFs (epithelial-to-mesenchymal transition transcription factors) are key regulators of epithelial plasticity in embryonic development. EMT-TFs expression is usually silenced in adults and can be reactivated in pathological processes such as organ fibrosis and carcinomas, but their role in melanoma is not understood. We aim to elucidate the mechanisms underlying melanoma plasticity. In particular, whether the reactivation of embryonic programmes and specifically EMT inducers contribute to melanoma initiation, progression and/or resistance to therapies.