Histone variants link chromatin architecture and metabolism
Ponente: Marcus Bushbeck
Josep Carreras Leukaemia Research Institute (IJC) [Barcelona, España]
Host: Pedro A. Lazo-Zbikowski
Fecha: 19/10/2017 - 19/10/2017
Salón de Actos del Centro de Investigación del Cáncer
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How do chromatin alterations contribute to cell fate transitions? How does the environment influence these processes? And how does the metabolic state of a cell impact on its chromatin structure and its epigenetic memory?
These are questions we address in the lab. Studying stem cells and cancer we focus on molecular aspects of epigenetic regulation and on the question whether we can translate this knowledge into diagnostic and therapeutic tools for the management of diseases such as leukemia and myelodysplastic syndrome.
In the seminar I will discuss the function of histone variants that link the architecture of the genome to metabolic regulation.