How can 3D structure knowledge help systems biology?
Ponente: Baldo Oliva Miguel
Universidad Pompeu Fabra (UPF) [Barcelona]
Host: Javier de las Rivas
Salón de actos del Centro de Investigación del Cáncer
The role of protein structures is fundamental to understand the mechanisms by which proteins work, not only on their own but also in cooperativity with their environment. Therefore, the formation of protein complexes can be crucial to comprehend the action mechanisms of a system, for example in the routes of transduction signals. Here, I propose the use of some examples to understand the implication of structure in the activity of cells. The first example is on the conformational change caused by phosphoryaltion that affects the activity of an enzyme (PARP1) and its implications on the changes of chromatin. Other two examples are the dimerization of NUDIX, affecting the production of ATP inside the nucleus of the cell and the control of cell proliferation by retinoblastoma. Finally, thanks to the use of bioinformatics, many of these approaches can be automated and applied high-throughput, helping us to study an unveil the mechanisms of action over a large set of data.