Role of microRNAs in B cell differentiation and neoplastic transformation.
Ponente: Virginia García de Yébenes Mena
Centro Nacional de Investigaciones Cardiovasculares (CNIC). Madrid
Host: Pedro A. Lazo-Zbikowski
Salón de actos del Centro de Investigación del Cáncer
Most of the lymphomas diagnosed in the Western world arise from the malignant transformation of mature B lymphocytes. microRNAs (miRNAs) are post-transcriptional critical regulators of numerous biological processes and their deregulation has been linked to multiple human pathologies, including cancer. The possibility of manipulating the expression of miRNAs in vivo by the delivery of miRNAs mimics or miRNA inhibitors has opened new therapeutic perspectives for the treatment of numerous diseases. My recent work has focused in the characterization of the role of miR-28 in the B cell immune response and the anti-tumoral effects of miR-28 in B cell malignancies. In this seminar, I plan to present my recent work on the clinical applications of microRNA restauration in non-Hodgkin lymphoma and an outline of my future research lines.