Molecular Mechanisms of Cancer Program
Xosé R. Bustelo
Basic scientists in this program aim at characterizing new oncogenic drivers, signaling elements, and pathobiological programs that participate in the origin, malignant progression, and therapeutic responsiveness of a variety of tumor subtypes. To this end, they use a multifaceted approach composed of in silico analyses, genomics, proteomics, genetically-modified mice, and cell models such as cell lines, organoids, and patient-derived xenografts. These analyses also allow the identification and validation of new drug targets as well as the design of new biomarkers and other diagnostic tools.