An epigenetic journey into the origin and evolution of B cell tumors

Beyond changes in the DNA sequence, lymphoid tumors are associated with widespread alterations in their epigenetic makeup. Understanding the epigenome and its multiple marks, including DNA methylation, histone modifications, chromatin accessibility and the 3D genome structure within the nucleus, is allowing us to obtain new insights into the cellular origin, pathogenetic mechanisms and clinical behavior of lymphoid neoplasms. In particular, we identified that epig