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Chromatin Conformation in Development and Disease

Chromatin Conformation in Development and Disease

Juan Manuel Vaquerizas

Max Planck Institute for Molecular Biomedicine [Münster, Germany]

Date: 17/01/2019
Time: 12:30:00
Salón de actos del Centro de Investigación del Cáncer
Mercedes Dosil

The three-dimensional organisation of the genome plays a fundamental role in the regulation of gene expression. Recent examinations of chromatin conformation have revealed the presence of hundreds of self-associating domains and thousands of regulatory loops between enhancers and target genes that ensure a correct deployment of developmental programmes. Mutations affecting these highly conserved and relatively tissue-unspecific regulatory features often result in striking developmental defect