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Clonal evolution of pre-malignant B-cells in the absence of AID

Clonal evolution of pre-malignant B-cells in the absence of AID

Guillermo Rodríguez-Hernández

Centro de Investigación del Cáncer, CIC-IBMCC, lab.13

Date: 14/02/2019
Time: 12:30:00
Salón de Actos del Centro de Investigación del Cáncer

Infections during early childhood have been associated to the development of childhood B-cell acute leukemia (B-ALL). We recently showed that natural exposure to infectious pathogen induced development of overt B-ALL in mouse models mimicking the human genetic predisposition to B-ALL. In addition to its role as central effector of somatic hypermutation and class-switch recombination in B-cells, AID contributes to B-cell transformation. Likewise, a recent mouse mod