How can 3D structure knowledge help systems biology?

The role of protein structures is fundamental to understand the mechanisms by which proteins work, not only on their own but also in cooperativity with their environment. Therefore, the formation of protein complexes can be crucial to comprehend the action mechanisms of a system, for example in the routes of transduction signals. Here, I propose the use of some examples to understand the implication of structure in the activity of cells. The first example is on th