Mechanisms and consequences of large nuclear deformation : from microchannels to mammary tumors.

In tissues, extracellular matrix fibers and cells limit space. Migrating and proliferating cells thus often face situations of crowding and confinement, which can result in strong cell deformations. We showed that, in the case of migrating immune and cancer cells, such strong deformation can result in transient events of nuclear envelope ruptures accompanied by DNA damage and repair. I will present new results from a study aiming at understanding the long-term con