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Mechanisms of regulation of the guanine nucleotide exchange factor C3G

Mechanisms of regulation of the guanine nucleotide exchange factor C3G

Arturo Carabias del Rey

Centro de Investigación del Cáncer (CIC-IBMCC), Salamanca

Date: 17/07/2019
Time: 12:30:00
Salón de actos del Centro de Investigación del Cáncer

C3G (also known as RapGEF1), is a guanine nucleotide exchange factor (GEF) for the small GTPases of the Ras family Rap1, Rap2, R-Ras, TC21 and for the Rho GTPase TC10. GEFs interact with GTPases and favor the switch from the inactive GDP-bound state to the active GTP-bound form. C3G participates in a large repertoire of cell functions and plays a prominent role in the control of cell adhesion and migration through the activation of Rap1. The GEFs of the Ras family