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Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses

Regnase-1, a key endoribonuclease responsible for the inflammatory and immune responses

Shizuo Akira

Laboratory of Host Defense, WPI Immunology Frontier Research Center, and Department of Host Defense, Research Institute for Microbial Diseases, University of Osaka [Osaka, Japan]

Date: 06/06/2019
Time: 12:30:00
Salón de actos del Centro de Investigación del Cáncer
Pedro A. Lazo-Zbikowski

Gene expression is controlled at multiple points, including signal transduction, transcription and mRNA stability. So far, transcriptional regulation has been extensively studied. However, recent studies have revealed that control of gene expression at the mRNA level is as important as transcriptional control in the immune response. We have shown that Regnase-1 encoded by the Zc3h12a gene is an endoribonuclease involved in destabilization of a variety of mRNAs inc