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Short-term activation of the Jun-N terminal Kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

Short-term activation of the Jun-N terminal Kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

Noelia Pinal Seoane

Centro de Biología Molecular "Severo Ochoa" (CBMSO) de Madrid

Date: 15/01/2019
Time: 12:30:00
Salón de Actos del Centro de Investigación del Cáncer
Pedro Lazo

In Drosophila the Jun-N terminal Kinase (JNK) pathway has a principal pro-apoptotic function aimed to eliminate aberrant cells that appear after stress or after oncogenic transformations. It also performs other non-apoptotic functions associated with morphogenesis and cell proliferation but experimental analysis of the latter is hindered by its pro-apoptotic activity. Here we report the response of apoptosis-deficient cells to short–term JNK inducti