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TARGETING RAS-PI3K SIGNALLING TO RE-EDUCATE THE STROMA OF RAS MUTANT LUNG CANCER.

TARGETING RAS-PI3K SIGNALLING TO RE-EDUCATE THE STROMA OF RAS MUTANT LUNG CANCER.

Cristina Cuesta Apausa

Centro de Investigación del Cáncer (CIC-IBMCC)

Date: 06/02/2020
Time: 12:30:00
Salón de actos del CIC

Lung cancer is the leading cause of cancer-related death worldwide. Non-small lung cancer (NSCLC), the most prevalent form of lung cancer (85% of cases), has a dismal ten-year survival rate of 5%. KRAS is aberrantly activated by mutations in 30% of NSCLC. Patients harbouring this mutation have an even worst prognosis and currently there are no therapies available in the clinic. Thus, there is a strong clinical need to understand the molecular biology of KRAS-drive