Logo CICANCER

Tumor genomes shed light into somatic mutational processes and cancer vulnerabilities.

Tumor genomes shed light into somatic mutational processes and cancer vulnerabilities.

Nuria López-Bigas

IRB, Barcelona

Date: 29/01/2020
Time: 12:00:00
Salón de actos del Centro de Investigación del Cáncer
Xosé Bustelo

Somatic mutations are the driving force of cancer genome evolution. The rate of somatic mutations appears to be greatly variable across the genome due to variations in chromatin organization, DNA accessibility and replication timing. In addition, other variables that influence the mutation rate in a local scale are starting to emerge. I will discuss recent findings from our lab on how DNA-binding proteins, nucleosomes and differences in exons and introns influence