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Vascular checkpoints for cancer immunotherapy

Vascular checkpoints for cancer immunotherapy

Santos Mañes

Centro Nacional de Biotecnologia (CNB) [Madrid, Spain]

Date: 04/07/2019
Time: 12:30:00
Salón de actos del Centro de Investigación del Cáncer
Xosé Bustelo

Cancer immunotherapy is based on the ability of immune cells, and in particular of T lymphocytes, to recognize neoantigens in tumor cells, and thus to cause their destruction. During their evolution, tumors develop multiple strategies that suppress T-cell based immune responses to evade their immunodestruction. One of these evasive mechanisms is based on the selective blockade of  the entry of effector T lymphocytes into the tumor microenvironment (TME), thus