Diversity of Quaternary Structures Regulates Nuclear Receptor Activities in Health and Disease
Institute of Biomedicine of the University of Barcelona (IBUB)
Nuclear receptors are master regulators of gene transcription and one of the most important protein families for therapeutic intervention to fight breast or prostate cancer among other key human pathologies. Crystal structures as well as recent electron microscopy structures reveal a diversity of quaternary architectures that are responsible for their patho-physiological actions. Understanding their atomic details are key to rationally design precision medicines with novel mechanisms of action.