PD-L2 upregulation and immune evasion in therapy-induced cellular senescence
José Alberto López Domínguez
Cellular Plasticity and Disease laboratory, IRB Barcelona
Senescent cells, damaged but persistent, accumulate in the aging organisms and in post-therapy tumors. Efficient detection and elimination of senescent cells are key to improve response to anti-tumor therapies. We show that PD-L2 expression protects senescent cells from the immune system, limiting the efficiency of current chemotherapies. In addition, we propose novel approaches to detect senescent cells by non-invasive, translatable methods.