Short-term activation of the Jun-N terminal Kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

In Drosophila the Jun-N terminal Kinase (JNK) pathway has a principal pro-apoptotic function aimed to eliminate aberrant cells that appear after stress or after oncogenic transformations. It also performs other non-apoptotic functions associated with morphogenesis and cell proliferation but experimental analysis of the latter is hindered by its pro-apoptotic activity. Here we report the response of apoptosis-deficient cells to short–term JNK inducti