The non-receptor tyrosine kinase ACK: signalling pathways and opportunities for therapeutic intervention.

In cancer, the acquisition of invasive and metastatic characteristics leads to incurable disease in the host. Small G proteins, particularly members of the Rho family, are known regulators of the actin cytoskeleton and therefore control the morphology and motility of mammalian cells. It is not surprising therefore, that they are implicated with increasing frequency in the transition to invasive and metastatic forms of cancers. Cdc42 is one such Rho family small G