Tissue-specific and time-dependent mechanisms of metastasis.

Metastatic progression relies on specific biological steps that need to be targeted to improve current therapeutic strategies. Chemotherapy targets high-proliferating tumor cells rather than the low-proliferating metastastic tumor cells, which can then spread from the primary tumor to distant sites, where they resist conventional treatments, proliferate, and cause vital organ failure. Strikingly, different BCa types show distinct metastatic organ tropism, and acqu