Tumor genomes shed light into somatic mutational processes and cancer vulnerabilities.
29/01/2020 to 01/01/0001
Salón de actos del Centro de Investigación del Cáncer
Somatic mutations are the driving force of cancer genome evolution. The rate of somatic mutations appears to be greatly variable across the genome due to variations in chromatin organization, DNA accessibility and replication timing. In addition, other variables that influence the mutation rate in a local scale are starting to emerge. I will discuss recent findings from our lab on how DNA-binding proteins, nucleosomes and differences in exons and introns influence