Precision Biology for Precision Medicine: Cancer Genomics in Hematological Malignancies
Xosé S. Puente
IUOPA-Universidad de Oviedo
Precision medicine in oncology relies on the molecular classification of tumors based on their mutational profile. Dr. Puente’s laboratory has contributed to the identification of the main driver mutations involved in the development of chronic lymphocytic leukemia and other hematological tumors. His work has expanded the number of driver alterations, including the identification of driver mutations in non-coding genes and non-coding regions, expanding the mechanisms contributing to tumorigenesis. Now the group is trying to apply novel bioinformatics tools to bring whole genome sequencing to the clinic.